Dehydroepiandrosterone sulfate (DHEA-S) is a hormone produced by the adrenal gland. This hormone is converted to other hormones such as testosterone and estrogen. The DHEA-S test measures the levels of DHEA-S in the blood, which can help diagnose and monitor adrenal gland function. It is commonly used to evaluate adrenal gland disorders such as Addison’s disease, congenital adrenal hyperplasia, and Cushing’s syndrome. DHEA-S levels can also be affected by certain medications, age, and gender, as well as various conditions such as polycystic ovary syndrome (PCOS) and depression. The DHEA-S test may be ordered alone or as part of a hormone panel to evaluate overall endocrine function.