The Hepatitis B envelope Antibody (Anti-HBe) test is a blood test that detects the presence of antibodies against the Hepatitis B virus envelope antigen. The test is used to monitor the progression of Hepatitis B infection and to assess the effectiveness of treatment. The envelope antigen is a protein that is present on the surface of the Hepatitis B virus and is involved in the replication of the virus. The presence of Anti-HBe antibodies indicates that the virus is in a less active stage and is less likely to be transmitted to others. The test is usually ordered for individuals who are chronically infected with Hepatitis B to monitor their disease progression and treatment response. A positive Anti-HBe test result indicates that the person has developed antibodies against the envelope antigen and the virus is in a less active stage. A negative result suggests that the virus is actively replicating and the person is at a higher risk of transmitting the virus to others. The Anti-HBe test is an important tool in the management of Hepatitis B and is often performed alongside other liver function tests and viral load tests.