LIVER-KIDNEY MICROSOME-1 AB (LKM 1)

Diagnosing the Body’s Attack on Its Own Liver Cells

The LKM Antibody Test detects the presence of autoantibodies (specifically Anti-LKM-1) that mistakenly target enzymes within your own liver and kidney cells. This test is a critical tool for diagnosing Autoimmune Hepatitis Type 2 (AIH-2).

In Autoimmune Hepatitis, your immune system—which is supposed to fight outside invaders—sees your own healthy liver tissue as a threat and launches a sustained attack. The LKM antibody acts like a highly specific "Self-Destruct" signal for the liver.

Why Do You Need This Test?

The LKM test is typically ordered by a Hepatologist (liver specialist) or Gastroenterologist when routine testing shows high liver enzymes (ALT/AST) and other common causes (Viral Hepatitis, Alcohol, Fatty Liver) have been ruled out. It is particularly relevant for:

• Differentiating AIH Types: LKM-1 is the primary marker for Autoimmune Hepatitis Type 2, which most commonly affects children and adolescents.
• Investigating Unexplained Hepatitis: When a patient presents with symptoms like fatigue, jaundice, and joint pain, but is negative for Hep A, B, and C.
• Monitoring Treatment: The level of LKM antibodies may be monitored to see if immunosuppressive medication is effectively calming the immune system.